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KMID : 0043319940170030166
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.166 ~ p.169
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Reduced Anti-inflammatory Activity of Acetylsalicylic Acid Maltol Ester, Aspalatone
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Han Byung-Hoon
Suh Dae-Yeon
Yang Hyun-Ok
Lee Song-Jin
Kim Hyun-Pyo
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Abstract
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The anti-inflammatory activity of acetylsalicylic acid maltol ester (aspalatone), a potential anti-thombotic agent, was studied using the several experimental animal models of inflammation. By oral administration, aspalatone was found to possess the weak anti-inflammatory activity in models of an acute inflammation, in which aspalatone showed approximately one-third to one-fourth of the anti-inflammatory activity of aspirin. Aspalatone (200 mg/kg/day) and aspirin (50 mg/kg/day), however, did not show the inhibitory activity against granuloma fomation and adjuvant-induced arthritis.
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KEYWORD
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Anti-inflammatory activity, aspalatone, aspirin, maltol, acute inflammation, chronic inflammation
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